Cellular Requirements for Systemic Control of Salmonella enterica Serovar Typhimurium Infections in Mice

• DOI: 10.1128/iai.02192-14
• Publication Date: 2014-09-16T05:57:57Z
• Authors: Andreas Kupz; Sammy Bedoui; Richard A. Strugnell
• Keywords: Salmonella enterica; Salmonella infection; Intracellular parasite; Cellular immunity

ABSTRACT The rational design of vaccines requires an understanding the contributions individual immune cell subsets to immunity. With this understanding, targeted vaccine delivery approaches and adjuvants can be developed maximize efficiency minimize side effects (S. H. E. Kaufmann et al., Immunity 33:555–577, 2010; T. Ben-Yedidia R. Arnon, Hum. Vaccines 1:95–101, 2005). We have addressed different their ability contribute control clearance facultative intracellular pathogen Salmonella enterica serovar Typhimurium ( S . Typhimurium) in a murine model. Using systematic reproducible model experimental attenuated infection, we show that distinct lymphocyte deficiencies lead one four infection outcomes: clearance, chronic early death, or late death. Our study demonstrates high level functional redundancy provide interferon gamma (IFN-γ), critical cytokine Whereas was entirely dependent on IFN-γ but not any particular subset, critically required CD4 + T cells appeared independent IFN-γ. These data reinforce idea bimodal response against : cell-independent IFN-γ-dependent phase cell-dependent may independent.