Role of Polymorphonuclear Neutrophils in a Murine Model ofChlamydia psittaci-Induced Abortion

• DOI: 10.1128/iai.67.5.2110-2116.1999
• Publication Date: 2019-12-31T15:34:18Z
• Authors: Antonio J. Buendía; Roberto Montes de...; Jose A. Navarro; Joaquín Sánchez; Francisco Cuello; Jesús Salinas
• Keywords: Chlamydia psittaci; Chlamydiae

ABSTRACT To assess the role of polymorphonuclear neutrophils (PMNs) in Chlamydia psittaci infection a pregnant mouse model, and nonpregnant Swiss OF1 mice were depleted PMNs by treatment with RB6-8C5 monoclonal antibody before intraperitoneal C. serotype 1. Nondepleted served as controls. Depleted aborted earlier had much higher mortality rate than nondepleted mice. Bacteriological analysis showed that number chlamydiae isolated from spleens at 5 7 days postinfection was 100 times greater Histopathological placentas widespread necrosis uteroplacental units, weak immunoreaction to chlamydial antigen, while substantial neutrophil infiltration but no large areas necrosis, moderate strong antigen. The livers numerous inclusions hepatocytes, delayed microgranuloma formation, animals extensive coagulative periportal necrosis. displayed multiple small foci mononuclear cells formation. Among this group mice, always more hepatic damage animals. Our results suggest play an essential response primary infection, preventing uncontrolled multiplication liver spleen.