Role of Gamma Interferon and Interleukin-4 in Host Defense against the Human Filarial ParasiteBrugia malayi

• DOI: 10.1128/iai.68.5.3034-3035.2000
• Publication Date: 2002-07-27T10:01:19Z
• Authors: Subash Babu; Lisa M. Ganley; Thomas R. Klei; Leonard D. Shultz; T. V. Rajan
• Keywords: Brugia malayi

We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that lack either IFN-gamma or IL-4 prolongs time required to achieve sterile immunity, suggesting both canonical type 1 2 responses are involved clearance infection.