Endogenous Interleukin-12 Is Not Required for Resolution ofChlamydophila abortus(Chlamydia psittaciSerotype 1) Infection in Mice

• DOI: 10.1128/iai.69.8.4808-4815.2001
• Publication Date: 2002-07-27T10:03:40Z
• Authors: Laura Del Rı́o; Antonio J. Buendı́a; Joaquı́n Sánchez; Marı́a C. Gallego; Marı́a R. Caro; Nieves Ortega; Juan Seva; Francisco J. Pall...; Francisco Cuello; Jesús Salinas
• Keywords: Chlamydophila; Chlamydia psittaci; Chlamydophila pneumoniae

ABSTRACT A Th1 immune response involving gamma interferon (IFN-γ) production is required to eliminate Chlamydophila abortus infections. In this study, the role of interleukin-12 (IL-12) in protecting against C. infection was investigated using IL-12 −/− and wild-type (WT) C57BL/6 mice determine Th1-promoting cytokine. were able a primary infection. However, there delay clearance bacteria when infected with sublethal dose , being associated lower IFN-γ. The low level IFN-γ essential for survival mice. Both WT developed infection, since they both produced immunoglobulin G2a antibody isotype. addition, given secondary infectious challenge protective host which resolved by lack resulted few infiltrating CD4 + T cells liver relative number mice, although CD8 slightly higher. more intense presented may have pathogenic effect, as animals showed higher morbidity after conclusion, these results suggest that expedites cytokine not establishment