Molecular Characterization of the Prototrophic Salmonella Mutants Defective for Intraepithelial Replication

• DOI: 10.1128/iai.71.4.2247-2252.2003
• Publication Date: 2003-03-24T23:07:27Z
• Authors: Akamol E. Suvarna...; Daniel V. Zurawski; Rebecca L. Guy; Murry A. Stein
• Keywords: Pathogenicity island; Auxotrophy

ABSTRACT Three Mu d J prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. Finlay, Proc. Natl. Acad. Sci. USA, 88: 11470-11474, 1991). mutS mutH are disrupted in mutants 3-11 12-23, ssaQ mutant 17-21. Further analysis revealed loss of pathogenicity island 2 function underlies the defect