F-Type Pyocins Are Diverse Noncontractile Phage Tail-Like Weapons for Killing Pseudomonas aeruginosa

• DOI: 10.1128/jb.00029-23
• Publication Date: 2023-06-01T14:01:24Z
• Authors: Senjuti Saha; Chidozie D. Ojobor; Annie Si Cong Li; Erik Mackinnon; Olesia I. North; Joseph Bondy-Denomy; Joseph S. Lam; Alexander W. Ensm...; Karen L. Maxwell; Alan R. Davidson
• Keywords: 0301 basic medicine; Pyocins; 03 medical and health sciences; Bacteriocins; Pseudomonas aeruginosa; Humans; Bacteriophages; Anti-Bacterial Agents

Pseudomonas aeruginosa is an opportunistic pathogen that causes antibiotic-resistant infections with high mortality rates, particularly in immunocompromised individuals and cystic fibrosis patients. Due to the increasing frequency of multidrug-resistant P. aeruginosa infections, there is great need for the development of alternative therapeutics.