New Virulence-Activated and Virulence-Repressed Genes Identified by Systematic Gene Inactivation and Generation of Transcriptional Fusions in Bordetella pertussis

• DOI: 10.1128/jb.182.20.5902-5905.2000
• Publication Date: 2002-07-27T10:00:58Z
• Authors: Rudy Antoine; Sylvie Alonso; Dominique Raze; Loïc Coutte; Sarah Lesjean; Eve Willery; Camille Locht; Françoise Jacob-...
• Keywords: Intimin; Bordetella

ABSTRACT An in silico scan of the partially completed genome sequence Bordetella pertussis and analyses transcriptional fusions generated with a new integrational vector were used to identify potential virulence genes. The genes encoding putative siderophore receptor, adhesins, an autotransporter protein appeared be regulated manner similar by global regulator BvgAS. In contrast, gene intimin-like repressed under conditions virulence.