The Quorum Sensing Negative Regulators EsaR and ExpR Ecc , Homologues within the LuxR Family, Retain the Ability To Function as Activators of Transcription

• DOI: 10.1128/jb.185.23.7001-7007.2003
• Publication Date: 2003-11-14T21:00:08Z
• Authors: Susanne B. von Bo...; Jessica K. Ball; Marie A. Faini; Carmen M. Herrera; Timothy D. Minogue; Mark L. Urbanowski; Ann M. Stevens
• Keywords: Transcription

Most LuxR homologues function as activators of transcription during the process quorum sensing, but a few, including EsaR and ExpR(Ecc), negatively impact gene expression. The LuxR-activated luxI promoter binding site, lux box, were used in artificial contexts to assess potential for transcriptional activation DNA by ExpR(Ecc). Although acyl-homoserine lactone responsiveness both proteins is opposite that shown most family members, ExpR(Ecc) have preserved ability interact with RNA polymerase activate despite their low affinity box DNA.