Homology Analysis of Pathogenic Yersinia Species Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis Based on Multilocus Sequence Typing

• DOI: 10.1128/jcm.02185-13
• Publication Date: 2013-10-17T03:06:17Z
• Authors: Ran Duan; Junrong Liang; Guoxiang Shi; Zhigang Cui; Rong Hai; Peng Wang; Yuchun Xiao; Kewei Li; Haiyan Qiu; Wenpeng Gu; Xiaoli Du; Huaiqi Jing; Xin Wang
• Keywords: Yersinia pseudotuberculosis; Yersinia enterocolitica; Multilocus sequence typing; Yersinia pestis; Yersinia Infections; Yersinia; Yersiniosis

We developed a multilocus sequence typing (MLST) scheme and used it to study the population structure evolutionary relationships of three pathogenic Yersinia species. MLST these species showed complex two clusters, one composed pseudotuberculosis pestis other enterocolitica. Within first cluster, predominant Y. type 90 (ST90) was linked ST43 by locus difference, 81.25% strains were from serotype O:1b, supporting hypothesis that descended O:1b pseudotuberculosis. also found worldwide-prevalent serotypes O:1a, O:3 predominated specific STs. The second cluster consisted nonpathogenic enterocolitica strains, which may not have identical formed relatively conserved group; most clustered within ST186 ST187. Serotypes O:3, O:8, O:9 separated into distinct blocks. Nonpathogenic STs more heterogeneous, reflecting genetic diversity through evolution. By providing better effective procedure for use with community, valuable information insights differences pathogens obtained.