Continued Evolution of H5N1 Influenza Viruses in Wild Birds, Domestic Poultry, and Humans in China from 2004 to 2009

• DOI: 10.1128/jvi.00413-10
• Publication Date: 2010-06-11T02:17:16Z
• Authors: Yanbing Li; Jianzhong Shi; Gongxun Zhong; Guohua Deng; Guobin Tian; Jinying Ge; Xianying Zeng; Jiasheng Song; Dongming Zhao; Liling Liu; Yongping Jiang; Yuntao Guan; Zhigao Bu; Hualan Chen
• Keywords: Newcastle Disease; H5N1 genetic structure

Despite substantial efforts to control H5N1 avian influenza viruses (AIVs), the have continued evolve and cause disease outbreaks in poultry infections humans. In this report, we analyzed 51 representative AIVs isolated from domestic poultry, wild birds, humans China during 2004 2009, 21 genotypes were detected based on whole-genome sequences. Twelve of southern bear similar H5 hemagglutinin (HA) genes (clade 2.3). These did not display antigenic drift could be completely protected against by A/goose/Guangdong/1/96 (GS/GD/1/96)-based oil-adjuvanted killed vaccine recombinant Newcastle virus vaccine, which been used China. addition, antigenically drifted viruses, represented A/chicken/Shanxi/2/06 (CK/SX/2/06), chickens several provinces northern The CK/SX/2/06-like are reassortants with newly emerged HA, NA, PB1 that GS/GD/1/96-based vaccines. also reacted poorly antisera generated clade 2.2 2.3 viruses. majority lethal mice ducks, while caused mild replicate ducks. Our results demonstrate circulating nature complex biological characteristics pose a challenge for pandemic preparedness.