A Single Mutation at Position 156 in the Envelope Protein of Tembusu Virus Is Responsible for Virus Tissue Tropism and Transmissibility in Ducks

• DOI: 10.1128/jvi.00427-18
• Publication Date: 2018-06-13T09:48:57Z
• Authors: Dawei Yan; Ying Shi; Haiwang Wang; Guoxin Li; Xuesong Li; Binbin Wang; Xin Su; Junheng Wang; Qiaoyang Teng; Jianmei Yang; Hongjun Chen; Qinfang Liu; Wenjun Ma; Zejun Li
• Keywords: Transmissibility (structural dynamics); Tissue tropism; Zika Virus; Flavivirus

Tembusu virus, similar to other mosquito-borne flaviviruses such as WNV, JEV, and BAGV, can be transmitted without the presence of mosquito vectors. We demonstrate that envelope protein TMUV its amino acid (S) at position 156 is responsible for tissue tropism transmission in ducks. The mutation S156P results disruption N-linked glycosylation 154 E changes conformation “150 loop” protein, which induces limited virus replication lungs abrogates between Our findings provide new knowledge about among