Antibodies against the gH/gL/UL128/UL130/UL131 Complex Comprise the Majority of the Anti-Cytomegalovirus (Anti-CMV) Neutralizing Antibody Response in CMV Hyperimmune Globulin

• DOI: 10.1128/jvi.00467-12
• Publication Date: 2012-04-26T00:16:40Z
• Authors: Ashley E. Fouts; Pamela Chan; Jean-Philippe Ste...; Richard Vandlen; Becket Feierbach
• Keywords: Cytomegalovirus

Anti-cytomegalovirus (anti-CMV) hyperimmune globulin (HIG) has demonstrated efficacy in preventing CMV disease solid-organ transplant patients as well congenital when administered to pregnant women. To identify the neutralizing component of cytomegalovirus (CMV-HIG), we performed serial depletions CMV-HIG on cell-surface-expressed antigens purified antigens. Using this approach, demonstrate that major antibody response is directed at gH/gL/UL128/UL130/UL131 complex, suggesting little role for anti-gB antibodies neutralization.