Efficacy in Pigs of Inactivated and Live Attenuated Influenza Virus Vaccines against Infection and Transmission of an Emerging H3N2 Similar to the 2011-2012 H3N2v

• DOI: 10.1128/jvi.01038-13
• Publication Date: 2013-07-04T08:20:19Z
• Authors: Crystal L. Loving; Kelly M. Lager; Amy L. Vincent; Susan L. Brockmeier; Phillip C. Gauger; Tavis K. Anderson; Pravina Kitikoon; Daniel R. Perez; Marcus E. Kehrli
• Keywords: Attenuated vaccine; Pandemic

ABSTRACT Vaccines provide a primary means to limit disease but may not be effective at blocking infection and pathogen transmission. The objective of the present study was evaluate efficacy commercial inactivated swine influenza A virus (IAV) vaccines experimental live attenuated (LAIV) against with H3N2 subsequent indirect transmission naive pigs. evaluated similar H3N2v detected in humans during 2011-2012, which associated contact agricultural fairs. One vaccine provided partial protection measured by reduced nasal shedding; however, contacts became infected, indicating that reduction shedding did prevent aerosol LAIV complete protection, none indirect-contact pigs infected. Clinical observed any group, including nonvaccinated animals, consistent observation infected contemporary reassortant viruses. Serum hemagglutination inhibition antibody titers challenge were predictive efficacy; following vaccination sterilizing immunity below level considered protective, yet group protected above level. While currently approved products fully transmission, certain benefit limitating shedding, zoonotic spillover antigenically viruses agriculture fairs when administered appropriately used conjunction additional control measures.