Naturally Occurring Frameshift Mutations in the tvb Receptor Gene Are Responsible for Decreased Susceptibility of Chicken to Infection with Avian Leukosis Virus Subgroups B, D, and E

• DOI: 10.1128/jvi.01770-17
• Publication Date: 2017-12-19T13:43:24Z
• Authors: Xinjian Li; Weiguo Chen; Huanmin Zhang; Aijun Li; Dingming Shu; Hongxing Li; Zhenkai Dai; Yiming Yan; Xinheng Zhang; Wencheng Lin; Jingyun Ma; Qingmei Xie
• Keywords: Stop codon

The group of highly related avian leukosis viruses (ALVs) in chickens are thought to have evolved from a common retroviral ancestor into six subgroups, A E and J. These ALV subgroups use diverse cellular proteins encoded by four genetic loci as receptors gain entry host cells. Hosts exposed ALVs might be under selective pressure develop resistance infection. Indeed, alleles previously been identified all receptor chickens.