Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33

• DOI: 10.1128/jvi.01939-12
• Publication Date: 2012-09-13T00:37:54Z
• Authors: Leopold Kong; Erick Giang; Travis Nieusma; Justin B. Robbins; Marc C. Deller; Robyn L. Stanfield; Ian A. Wilson; Mansun Law
• Keywords: Envelope (radar)

ABSTRACT We have determined the crystal structure of broadly neutralizing antibody (bnAb) AP33, bound to a peptide corresponding hepatitis C virus (HCV) E2 envelope glycoprotein antigenic site 412 423. Comparison with bnAb HCV1 same epitope reveals different angle approach antigen by AP33 and slight variation in its β-hairpin conformation epitope. These structures establish two modes binding that antibodies adopt neutralize diverse HCV.