Vaccine-Induced CD107a+CD4+T Cells Are Resistant to Depletion following AIDS Virus Infection

• DOI: 10.1128/jvi.02032-14
• Publication Date: 2014-10-02T08:30:33Z
• Authors: Kazutaka Terahara; Hiroshi Ishii; Takushi Nomura; Naofumi Takahashi; Akiko Takeda; Teiichiro Shiino; Yasuko Tsunetsugu...; Tetsuro Matano
• Keywords: Simian immunodeficiency virus; Viremia

ABSTRACT CD4 + T-cell responses are crucial for effective antibody and CD8 induction following virus infection. However, virus-specific T cells can be preferential targets human immunodeficiency (HIV) HIV-specific by vaccination may thus result in enhancement of replication In the present study, we show that vaccine-elicited expressing CD107a relatively resistant to depletion a macaque AIDS model. Comparison CD107a, macrophage inflammatory protein-1β, gamma interferon, tumor necrosis factor alpha, interleukin-2 vaccinated macaques prechallenge 1 week postchallenge showed significant reduction − but not subset after exposure. Those vaccinees failed control viremia more marked exhibited significantly higher viral loads at than unvaccinated animals. Our results indicate vaccine-induced depleted infection, suggesting rationale avoiding HIV vaccine design. IMPORTANCE Induction and/or is principal strategy against induction. Here, largely infection While important control, our lead efficient rather detrimental accelerate acute phase. This suggests design should avoid Conversely, this study found challenge, implying these an alternative approach toward control.