Intrarectal transmission of simian immunodeficiency virus in rhesus macaques: selective amplification and host responses to transient or persistent viremia

• DOI: 10.1128/jvi.70.10.6876-6883.1996
• Publication Date: 2020-01-06T21:38:58Z
• Authors: P Trivedi; D Horejsh; S B Hinds; I I Hinds PW; M S Wu; M S Salvato; C D Pauza
• Keywords: Viremia; Simian immunodeficiency virus

Intrarectal simian immunodeficiency virus (SIV) infection in rhesus macaques is a model for sexual transmission of primate retroviruses. Phylogenetic studies on envelope gene sequences that were present blood following intrarectal SIV inoculation provided evidence selective amplification subset viruses the inoculum and defined one amino acid sequence uniquely associated with infection. Both persistent transient viremia states observed after Immune responses persistently infected animals accounted slower rates disease progression despite presence highly pathogenic documented by transfusion studies. Transient elicited protective immunity against subsequent challenge but did not protect intravenous challenge. usually always led to self-limiting In animal, we relapse active long initial viremia. across mucosal barriers affects pathogenesis short term limiting types established host longer establishing slow blood.