Syndecans Serve as Attachment Receptors for Human Immunodeficiency Virus Type 1 on Macrophages

• DOI: 10.1128/jvi.75.19.9187-9200.2001
• Publication Date: 2002-07-27T10:06:37Z
• Authors: Andrew C. S. Saphire; Michael D. Bobardt; Zhe Zhang; Guido David; Philippe A. Gallay
• Keywords: Cell type; Syndecan 1

ABSTRACT Macrophages are thought to represent one of the first cell types in body be infected during early stage human immunodeficiency virus type 1 (HIV-1) transmission and a potential viral reservoir vivo. Thus, an understanding HIV-1 attachment these cells is fundamental development novel anti-HIV-1 therapies. Although major targets vivo—CD4 + T lymphocytes—express high CD4 levels, other such as macrophages do not. We asked this study whether low level on sufficient support or surface proteins than required for process. show that alone not initial adsorption macrophages. Importantly, we find heparan sulfate proteoglycans (HSPGs) serve main class receptors Most importantly, demonstrate single family HSPGs, syndecans, efficiently mediates represents abundant