Subclinical Prion Disease Induced by Oral Inoculation

• DOI: 10.1128/jvi.77.14.7991-7998.2003
• Publication Date: 2003-06-26T17:57:37Z
• Authors: Alana M. Thackray; Michael A. Klein; Raymond Bujdoso
• Keywords: Subclinical infection; Infectivity

ABSTRACT Natural transmission of prion disease is believed to occur by peripheral infection such as oral inoculation. Following this route inoculation, both the nervous system and lymphoreticular may be involved in subsequent neuroinvasion central prions, which not necessarily result clinical signs terminal disease. Subclinical disease, characterized presence infectivity PrP Sc absence overt signs, occur. It known host factors contribute whether with prions culminates a or subclinical state. We have investigated level c protein expression factor development When RML inoculum was inoculated either i.c. intraperitoneal route, wild-type tga20 mice succumbed In contrast, orally whereas showed no signs. However, sacrificed 375 525 days after inoculation harbored significant levels brain infectivity. These data show that same-species animals express normal can This indicates contributing regulation Events increase predispose prion-infected animal more deleterious effects pathology.