Transmission Study of Andes Hantavirus Infection in Wild Sigmodontine Rodents

• DOI: 10.1128/jvi.78.21.11972-11979.2004
• Publication Date: 2004-10-12T17:40:21Z
• Authors: P. Padula; R. Figueroa; M. Navarrete; E. Pizarro; R. Cadiz; C. Bellomo; C. Jofre; L. Zaror; E. Rodriguez; R. Murúa
• Keywords: Sigmodontinae; Disease reservoir

ABSTRACT Our study was designed to contribute an understanding of the timing and conditions under which transmission Andes hantavirus in Oligoryzomys longicaudatus reservoir populations takes place. Mice were caged test habitats consisting steel drums containing holding cages, where seronegative rodents exposed wild seropositive individuals by freely sharing same cage or being separated a wire mesh. Tests also performed for potential viral mice from excrement-tainted bedding cages. virus transmitted efficiently; 130 attempts with direct contact, 12.3% resulted transmission. However, if we consider only those that proved be infectious, 93 obtained 16 infected animals (17.2%). Twelve them intraspecies O. encounters male differentially affected 4 Abrothrix olivaceus . Experiments using longipilis as receptors not successful. Transmission observed between mesh-separated animals, bedding. Bites seemed requisite oral Genomic RNA amplified two out three saliva samples rodents, but it detected urine vesicle puncture other rodents. Immunohistochemistry, antibodies against (AND) proteins, revealed strong reactions lung salivary glands, supporting possibility suggests AND may principally via aerosols rather than feces urine.