CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study

• DOI: 10.1128/mbio.01212-23
• Publication Date: 2023-09-01T13:02:04Z
• Authors: Isabel Neale; Mohammad Ali; Barbara Kronsteiner; Stephanie Longet; Priyanka Abraham; Alexandra S. Deeks; Anthony Brown; Shona C. Moore; Lizzie Stafford; Susan L. Dobson; Megan Plowright; Thomas A. H. Newman; Mary Y. Wu; ; Edward J. Carr; Rupert Beale; Ashley D. Otter; Susan Hopkins; Victoria Hall; Adriana Tomic; Rebecca P. Payne; Eleanor Barnes; Alex Richter; Christopher J. A....; Lance Turtle; Thushan I. de Silva; Miles Carroll; Teresa Lambe; Paul Klenerman; Susanna Dunachie
• Keywords: Seroconversion

Defining correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infection informs policy for booster doses and future designs. Existing studies demonstrate humoral protection, but the role T cells in is still unclear. In this study, we explore antibody cell immune responses associated with Delta variant a well-characterized cohort UK Healthcare Workers (HCWs). We evidence to support CD4+ CD8+ as well antibodies infection. addition, our results suggest potential cross-reactive breakthrough.