SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells

• DOI: 10.1128/mbio.02415-22
• Publication Date: 2022-09-20T13:02:37Z
• Authors: Long C. Nguyen; David M. Renner; Diane Silva; Dongbo Yang; Nicholas A. Parenti; Kaeri M. Medina; Vlad Nicolaescu; Haley Gula; Nir Drayman; Andrea Valdespino; Adil Mohamed; Christopher Dann; Kristin Wannemo; Lydia Robinson-Ma...; Alan Gonzalez; Letícia Stock; Mengrui Cao; Zeyu Qiao; Raymond E. Moelle...; Savas Tay; Glenn Randall; Michael F. Beers; Marsha Rich Rosner; Scott A. Oakes; Susan R. Weiss
• Keywords: Coronavirus; XBP1; Betacoronavirus; 2019-20 coronavirus outbreak

SARS-CoV-2 is the third lethal respiratory coronavirus, after MERS-CoV and SARS-CoV, to emerge this century, causing millions of deaths worldwide. Other common coronaviruses such as HCoV-OC43 cause less severe disease.