DNA Methylation and RNA-DNA Hybrids Regulate the Single-Molecule Localization of a DNA Methyltransferase on the Bacterial Nucleoid

• DOI: 10.1128/mbio.03185-22
• Publication Date: 2023-01-16T14:01:34Z
• Authors: Nicolas L. Fernandez; Ziyuan Chen; David E. H. Fuller; Lieke A. van Gijt...; Taylor M. Nye; Julie S. Biteen; Lyle A. Simmons
• Keywords: DNA, Bacterial; 0301 basic medicine; 570; replisome; Bacterial; DNA; Methyltransferases; DNA Methylation; 540; Microbiology; QR1-502; 3. Good health; restriction modification; superresolution microscopy; 03 medical and health sciences; RNA; DNA Restriction-Modification Enzymes; Bacteriophages; epigenetic; Bacillus subtilis; Research Article

DNA methyltransferases (MTases) influence gene expression, cell cycle control, and host defense through DNA modification. Predicted MTases are pervasive across bacterial genomes, but the vast majority remain uncharacterized.