Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions

• DOI: 10.1128/mbio.03464-21
• Publication Date: 2022-06-06T12:31:10Z
• Authors: Jeffrey S. Bourgeois; Caroline E. Anderson; Liuyang Wang; Jennifer L. Modli...; Wei Chen; Benjamin H. Schott; Nicolas Devos; Dennis C. Ko
• Keywords: Transcription

While recent breakthroughs have enabled intense study of bacterial DNA modifications, limitations in current work potentiated a surprisingly untested narrative that methylation is common mechanism the response to environmental conditions. Essentially, whether epigenetic regulation transcription common, generalizable phenomenon critical unanswered question we address here.