Exon Switching and Activation of Stromal and Embryonic Fibroblast Growth Factor (FGF)-FGF Receptor Genes in Prostate Epithelial Cells Accompany Stromal Independence and Malignancy

• DOI: 10.1128/mcb.13.8.4513-4522.1993
• Publication Date: 2021-06-06T08:18:05Z
• Authors: Guochen Yan; Yoshitatsu Fukabori; George McBride; Stathis Nikolarop...; Wallace L. McKeehan
• Keywords: Male; 0301 basic medicine; Base Sequence; RNA Splicing; Molecular Sequence Data; Prostate; Gene Expression; Prostatic Neoplasms; Cell Differentiation; Exons; Receptors, Fibroblast Growth Factor; Epithelium; Rats; Fibroblast Growth Factors; 03 medical and health sciences; Oligodeoxyribonucleotides; Tumor Cells, Cultured; Animals; Keratins; RNA, Messenger

Stroma and the heparin-binding fibroblast growth factor (FGF) family influence normal epithelial cell differentiation in embryonic adult tissues. The role of stromal cells expression isoforms FGF ligand receptor were examined during malignant progression from a differentiated, slowly growing, nonmalignant model rat prostate tumor. In syngeneic hosts, mixture resulted tumors which differentiated growing. absence cells, progressed to independent stroma undifferentiated. independence was accompanied by switch exclusive exon IIIb IIIc 2 (FGF-R2) gene. FGF-R2(IIIb) isoform displays high affinity for cell-derived FGF-7, whereas FGF-R2(IIIc) does not recognize FGF-7 but has FGF-2 member family. exclusively resident FGF-R2 gene followed activation gene, normally FGF-R1 FGF-3 FGF-5 genes cells. Multiple autocrine potentially intracrine ligand-receptor loops resulting these alterations within FGF-FGF-R may underlie autonomy tumor