Differential Spleen Remodeling Associated with Different Levels of Parasite Virulence Controls Disease Outcome in Malaria Parasite Infections

• DOI: 10.1128/msphere.00018-15
• Publication Date: 2015-12-07T18:46:00Z
• Authors: Ximei Huang; Sha Huang; Lai Chun Ong; Jason Chu-Shern Lim; Rebecca Joan Mary...; Annals Tatenda Mu...; Paul Thomas Matsu...; Jongyoon Han; Peter Rainer Preiser
• Keywords: Parasitic Disease; Parasite load

The spleen and its response to parasite infection are important in eliminating parasites malaria. By comparing P. yoelii lines with different disease outcomes mice that had either intact spleens or their removed, we showed upon infection, the exhibits dramatic changes can affect clearance. itself directly impacts RBC deformability independently of genetics. data indicated biomechanical properties malaria parasite-infected RBCs result complex interaction between host parasite, serve as a novel predictor clinical outcome. results also suggest early responses key factor directing outcome an infection.