Kinome-Wide RNA Interference Screening Identifies Mitogen-Activated Protein Kinases and Phosphatidylinositol Metabolism as Key Factors for Rabies Virus Infection

• DOI: 10.1128/msphere.00047-19
• Publication Date: 2019-05-21T13:42:50Z
• Authors: Benoit Besson; Seonhee Kim; Taehee Kim; Yoonae Ko; Sangchul Lee; Florence Larrous; Jihwan Song; David Shum; Regis Grailhe; Hervé Bourhy
• Keywords: Kinome

Rabies virus relies on cellular machinery for its replication while simultaneously evading the host immune response. Despite their importance, little is known about key factors required rabies infection. Here, we focused human kinome, at core of many pathways, to unveil a new understanding infectious cycle and discover potential therapeutic targets in small interfering RNA screening. The mitogen-activated protein kinase pathway phosphatidylinositol metabolism were identified as prominent involved infection, those findings further confirmed neurons. While bringing insight into biology, also provide list