Ex VivoCytokine Release, Determined by a Multiplex Cytokine Assay, in Response to Coccidioidal Antigen Stimulation of Whole Blood among Subjects with Recently Diagnosed Primary Pulmonary Coccidioidomycosis

• DOI: 10.1128/msphere.00065-18
• Publication Date: 2018-05-15T08:20:53Z
• Authors: Neil M. Ampel; Ian Robey; Chinh T. Nguyen; Brentin Roller; Jessica August; Kenneth S. Knox; Demosthenes Pappa...
• Keywords: Ex vivo

Coccidioidomycosis, commonly known as Valley fever, is a common pneumonia in the southwestern United States. In this paper, we examined release of 30 inflammatory proteins whole-blood samples obtained from persons with coccidioidal after blood were incubated preparation made causative fungus, Coccidioides . We found that six these proteins, all cytokines, specifically released high concentrations patients. Three cytokines seen very early disease, and an assay for might serve marker diagnosis fever.