Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit Autophagy by Interaction with Rab1A

• DOI: 10.1128/msphere.00549-21
• Publication Date: 2021-08-04T15:51:18Z
• Authors: Emily J. Strong; Tony W. Ng; Steven A. Porcelli; Sunhee Lee
• Keywords: 0301 basic medicine; Antigen Presentation; Macrophages; Mycobacterium tuberculosis; Microbiology; QR1-502; 3. Good health; Mice, Inbred C57BL; rab1 GTP-Binding Proteins; Mice; 03 medical and health sciences; RAW 264.7 Cells; Bacterial Proteins; Host-Pathogen Interactions; Autophagy; Animals; Research Article

Tuberculosis is a significant global infectious disease caused by infection of the lungs with Mycobacterium tuberculosis , which then resides and replicates mainly within host phagocytic cells. Autophagy is a complex host cellular process that helps control intracellular infections and enhance innate and adaptive immune responses.