Mouse Genetic Background Affects Transfer of an Antibiotic Resistance Plasmid in the Gastrointestinal Tract

• DOI: 10.1128/msphere.00847-19
• Publication Date: 2020-01-28T09:40:07Z
• Authors: Logan C. Ott; Zachary R. Stromberg; Graham A. J. Redweik; Michael J. Wannem...; Melha Mellata
• Keywords: Salmonella enterica

Antibiotic resistance is a threat to public health. Many clinically relevant antibiotic genes are carried on plasmids that can be transferred other bacterial members in the gastrointestinal tract. The current study used murine model transfer of large plasmid from foodborne Salmonella strain gut commensal E. coli We found different mouse genetic backgrounds and diversity microbial communities influenced level Escherichia acquired This suggests complexity community host genetics influence donor recipient bacteria.