Identification of Nasal Gammaproteobacteria with Potent Activity against Staphylococcus aureus: Novel Insights into the “Noncarrier” State

• DOI: 10.1128/msphere.01015-20
• Publication Date: 2021-01-05T14:26:52Z
• Authors: Amy L. Cole; Meera Sundar; Ana Lopez; Anna Forsman; Shibu Yooseph; Alexander M. Cole
• Keywords: 0301 basic medicine; Staphylococcus aureus; Microbiota; Epithelial Cells; Microbiology; QR1-502; Anti-Bacterial Agents; 3. Good health; 03 medical and health sciences; Antibiosis; Carrier State; Humans; Nasal Cavity; Cells, Cultured; Gammaproteobacteria; Research Article

Nasal carriage of Staphylococcus aureus is a risk factor for infection, but it is not yet understood why some individuals carry nasal S. aureus persistently, intermittently, or seemingly not at all when tested via culture methods. This study compared the nasal microbiomes of established S. aureus carriers and noncarriers, identified species associated with noncarriage, and tested them for anti- S. aureus activity using assays developed to model the nutrient-limited nasal mucosa.