Mining of Thousands of Prokaryotic Genomes Reveals High Abundance of Prophages with a Strictly Narrow Host Range

• DOI: 10.1128/msystems.00326-22
• Publication Date: 2022-07-26T13:01:17Z
• Authors: Gamaliel López-Leal; Laura Carolina Ca...; Juan Manuel Hurta...; Jérôme Verleyen; Santiago Castillo...; Alejandro Reyes-M...
• Keywords: Prophage

Phages and prophages are one of the principal modulators microbial populations. However, much their diversity is still poorly understood. Here, we extracted 33,624 from 13,713 complete prokaryotic genomes to explore prophage relationships with host. Our results reveal that were present in 75% studied. In addition, Enterobacterales significantly enriched prophages. We also found pathogens a significant reservoir Finally, determined relatedness range genomic hosts delimited by evolutionary hosts. On broader level, got insights into population, identified thousands publicly available genomes, comparing distribution between them IMPORTANCE play an essential role controlling host populations either modulating abundance or providing genes benefit The constant growth next-generation sequencing technology has caused development powerful computational tools identify phages high precision. Making it possible integrated on large scale. new under-explored area, efforts required understand dynamics