Impacts of the Plateau Environment on the Gut Microbiota and Blood Clinical Indexes in Han and Tibetan Individuals

• DOI: 10.1128/msystems.00660-19
• Publication Date: 2020-01-20T09:38:23Z
• Authors: Zhilong Jia; Xiaojing Zhao; Xiaoshuang Liu; Le Zhao; Qian Jia; Jinlong Shi; Xiao Xu; Lijun Hao; Zhenguo Xu; Qin Zhong; Kang Yu; Saijia Cui; Huining Chen; Jianying Guo; Xiang Li; Yang Han; Xinyu Song; Chenghui Zhao; Xiaochen Bo; Yaping Tian; Weidong Wang; Guotong Xie; Qiang Feng; Kunlun He
• Keywords: 0301 basic medicine; 03 medical and health sciences; clinical indexes; gut microbiota; plateau environment; Microbiology; QR1-502; Research Article

The intestinal microbiota is significantly affected by the external environment, but our understanding of effects extreme environments such as plateaus far from adequate. In this study, we systematically analyzed variation in and 76 blood clinical indexes among 393 healthy adults with different plateau living durations (Han individuals no living, for 4 to 6 days, >3 months, who returned plain 3 well plateau-living Tibetans). results showed that high-altitude environment rapidly (4 days) continually (more than months) shaped both Han population. With prolongation general characteristics population were increasingly similar those Tibetan area months still resembled rather on plain. Moreover, glucose lower groups nonplateau groups, while opposite result was obtained testosterone. Interestingly, there Tibetan-specific correlations between levels Succinivibrio Sarcina abundance intestine. study suggest a hypoxic could lastingly affect human indexes, providing new insights adaptability.IMPORTANCE data presented present demonstrate has profound impact gut individuals. plateau-changed signatures not restored status cohorts, even when several months. Our will improve great adaptation mechanism intervention targets adaptation.