Candida Administration Worsens Uremia-Induced Gut Leakage in Bilateral Nephrectomy Mice, an Impact of Gut Fungi and Organismal Molecules in Uremia

• DOI: 10.1128/msystems.01187-20
• Publication Date: 2021-01-11T13:04:38Z
• Authors: Wimonrat Panpetch; Chitrasak Kullapa...; Cong Phi Dang; Peerapat Visitcha...; Wilasinee Saisorn; Jutamas Wongphoom; Dhammika Leshan W...; Arthid Thim-uam; Kanitha Patarakul; Naraporn Somboonna; Somying Tumwasorn; Asada Leelahavani...
• Keywords: 0301 basic medicine; bilateral nephrectomy; Physiology; Nursing; FOS: Health sciences; Microbiology; gut leakage; 03 medical and health sciences; uremia; Effects of Ketogenic Diet on Health; Endocrinology; Biochemistry, Genetics and Molecular Biology; Health Sciences; Candida albicans; Gut Microbiota; Molecular Biology; Biology; Internal medicine; Uremia; Nutrition and Dietetics; gut microbiota; Life Sciences; Diversity and Function of Gut Microbiome; Provision and Assessment of Nutrition Support Therapy; QR1-502; 3. Good health; probiotics; FOS: Biological sciences; Medicine; Research Article

The impact of fungi in the intestine on acute uremia was demonstrated by the oral administration of Candida albicans in mice with the removal of both kidneys. Because fungi in the mouse intestine are less abundant than in humans, a Candida -administered mouse model has more resemblance to patient conditions.