Tonsillar Microbiota: a Cross-Sectional Study of Patients with Chronic Tonsillitis or Tonsillar Hypertrophy

• DOI: 10.1128/msystems.01302-20
• Publication Date: 2021-03-15T13:32:02Z
• Authors: Shengru Wu; Lalle Hammarstedt...; Mattias Jangard; Liqin Cheng; Sebastian Alexand...; Pia Angelidou; Yinghua Zha; Marica Hamsten; Lars Engstrand; Juan Du; Anders Ternhag
• Keywords: Veillonella; Streptococcus anginosus; Capnocytophaga; Prevotella

Chronic tonsillitis (CT) and tonsillar hypertrophy (TH) are common diseases that related to infection inflammation. Little is known about microbiota its role in CT TH. This study aims identify palatine both on the surface core tissues of TH patients. In total, 22 tonsils were removed collected from patients who underwent surgery. The compared using 16S rRNA gene sequencing V3-V4 regions. Differential microbiotas found versus tissues. Further, a higher relative abundance bacterial genera, including Haemophilus, Streptococcus, Neisseria, Capnocytophaga, Kingella, Moraxella, Lachnospiraceae [G-2] with Dialister, Parvimonas, Bacteroidales [G-2], Aggregatibacter, Atopobium CT, was observed. Of these, differential genera Neisseria served as key factors network. Notably, four representable microbial types identified, one, consisting Haemophilus exclusively detected analyzed different Several bacteria various along potential networks immune pathways.IMPORTANCE human has been shown be functionally connected infectious inflammation-related diseases. So far, only limited studies had performed microbiota, although play an essential defense system encountered numerous microorganisms. Our work presented chronic one type, which contains Furthermore, certain bacteria, such may serve biomarkers discriminate These data provide important research area highly useful for researchers oral microbiome field clinical field.