Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus

• DOI: 10.1128/spectrum.00010-21
• Publication Date: 2021-06-13T22:42:19Z
• Authors: Jacob L. Steenwyk; Matthew E. Mead; Patrícia Alves de...; Clara Valero; André Damasio; Renato A. C. dos ...; Abigail L. Labella; Yuanning Li; Sonja L. Knowles; Huzefa A. Raja; Nicholas H. Oberlies; Xiaofan Zhou; Oliver A. Cornely; Frieder Fuchs; Philipp Koehler; Gustavo H. Goldman; Antonis Rokas
• Keywords: Male; Antifungal Agents; virulence factors; Secondary Metabolism; Microbial Sensitivity Tests; Microbiology; Polymorphism, Single Nucleotide; Article; superinfection; secondary infection; pathogenicity; Humans; Metabolomics; Aged; Virulence; SARS-CoV-2; Aspergillus fumigatus; COVID-19; Genomics; acute respiratory distress syndrome; Middle Aged; coinfection; QR1-502; 3. Good health; Aspergillus; Phenotype; Mutation; Female; Pulmonary Aspergillosis; Research Article

The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has already killed millions of people. COVID-19 patient outcome can be further complicated by secondary infections, such as COVID-19-associated pulmonary aspergillosis (CAPA).