In Vitro Activity of Rifampin, Rifabutin, and Rifapentine against Enterococci and Streptococci from Periprosthetic Joint Infection

• DOI: 10.1128/spectrum.00071-21
• Publication Date: 2021-07-14T14:30:55Z
• Authors: Mariana Albano; Melissa J. Karau; Kerryl E. Greenwo...; Douglas R. Osmon; Caitlin P. Oravec; Daniel J. Berry; Matthew P. Abdel; Robin Patel
• Keywords: Rifabutin; Rifapentine; Rifamycin; Streptococcus mitis

After staphylococci, streptococci and enterococci are the most frequent causes of periprosthetic joint infection (PJI). MICs minimum biofilm bactericidal concentrations rifampin, rifabutin, rifapentine were determined for 67 enterococcal 59 streptococcal PJI isolates. Eighty-eight isolates had rifampin ≤1 μg/ml, among which rifabutin ≤ 8 ≤4 respectively. There was low rifamycin in vitro antibiofilm activity except a subset Streptococcus mitis group IMPORTANCE Rifampin is an antibiotic with antistaphylococcal used management staphylococcal irrigation debridement component retention; some patients unable to receive due drug interactions or intolerance. We recently showed have against planktonic states rifampin-susceptible infection-associated staphylococci. combined common infection. Here, we investigated 126 Enterococcus In contrast our prior findings biofilms, there PJI-associated enterococci, apart from