The small RNA PrrH aggravates Pseudomonas aeruginosa -induced acute lung injury by regulating the type III secretion system activator ExsA

• DOI: 10.1128/spectrum.00626-23
• Publication Date: 2024-01-30T18:32:54Z
• Authors: Qixuan Shi; Shenghe Zeng; Ruiqi Yu; Mo Li; Cong Shen; Xuan Zhang; Chanjing Zhao; Jianming Zeng; Bin Huang; Jieying Pu; Cha Chen
• Keywords: Pyocyanin; Virulence factor

is an opportunistic pathogen that causes acute and chronic infections in immunocompromised individuals. Small regulatory RNAs (sRNAs) regulate multiple bacterial adaptations to environmental changes, especially virulence. Our previous study showed sRNA PrrH negatively regulates the expression of a number virulence factors, such as pyocyanin, rhamnolipid, biofilm, elastase