Clinical and Molecular Characteristics and Antibacterial Strategies of Klebsiella pneumoniae in Pyogenic Infection

• DOI: 10.1128/spectrum.00640-23
• Publication Date: 2023-06-21T14:25:42Z
• Authors: Zhiyu Yang; Runmei Zhou; Yusheng Chen; Xiaotuan Zhang; Luogen Liu; Min Luo; Jinlin Chen; Kuilin Chen; Tong Zeng; Bin Liu; Yuan Wu; Jielite Huang; Zhuoran Liu; Jinglin Ouyang
• Keywords: classical Klebsiella pneumoniae; Virulence Factors; antibacterial strategies; Hypervirulent Klebsiella pneumoniae; Microbiology; QR1-502; 3. Good health; Anti-Bacterial Agents; Klebsiella Infections; Klebsiella pneumoniae; clinical and molecular characteristics; C-Reactive Protein; Humans; pyogenic infection; Procalcitonin; Biomarkers; Research Article

Treatment of Klebsiella pneumoniae causing pyogenic infections is challenging. The clinical and molecular characteristics are poorly understood, antibacterial treatment strategies limited. We analyzed the K. from patients with used time-kill assays to reveal bactericidal kinetics antimicrobial agents against hypervirulent (hvKp). A total 54 isolates were included, comprising 33 hvKp 21 classic (cKp) isolates, cKp identified using five genes (iroB, iucA, rmpA, rmpA2, peg-344) that have been applied as strain markers. median age all cases was years (25th 75th percentiles, 50.5 70), 62.96% individuals had diabetes, 22.22% sourced without underlying disease. ratios white blood cells/procalcitonin C-reactive protein/procalcitonin potential markers for identification suppurative infection caused by cKp. classified into 8 sequence type 11 (ST11) 46 non-ST11 strains. ST11 strains carrying multiple drug resistance a multidrug phenotype, while only intrinsic generally susceptible antibiotics. Bactericidal revealed not easily killed antimicrobials at breakpoint concentrations compared Given varied features catastrophic pathogenicity pneumoniae, it critical determine such optimal management effective infections. IMPORTANCE may cause infections, which potentially life-threatening bring great challenges management. However, various found most diseases, diabetes. ratio cells procalcitonin protein differentiating classical more resistant antibiotics than isolates. Most importantly, tolerant