Jerveratrum-Type Steroidal Alkaloids Inhibit β-1,6-Glucan Biosynthesis in Fungal Cell Walls

• DOI: 10.1128/spectrum.00873-21
• Publication Date: 2022-01-12T15:33:33Z
• Authors: Karen Kubo; Kaori Itto-Nakama; Shinsuke Ohnuki; Yoko Yashiroda; Sheena C. Li; Hiromi Kimura; Yumi Kawamura; Yasuhiro Shimamoto; Ken-Ichi Tominaga; Daisuke Yamanaka; Yoshiyuki Adachi; Shinichiro Takashima; Yoichi Noda; Charles Boone; Yoshikazu Ohya
• Keywords: Pathogenic fungus

Non- Candida albicans species (NCAC) are on the rise as a cause of mycosis. Many antifungal drugs less effective against NCAC, limiting available therapeutic agents.