Emergence of a Novel Plasmid-Mediated Tigecycline Resistance Gene Cluster, tmexCD4-toprJ4 , in Klebsiella quasipneumoniae and Enterobacter roggenkampii

• DOI: 10.1128/spectrum.01094-22
• Publication Date: 2022-07-06T13:01:52Z
• Authors: Xun Gao; Chengzhen Wang; Luchao Lv; Xiaotong He; Zhongpeng Cai; Wanyun He; Tong Li; Jian-Hua Liu
• Keywords: 0303 health sciences; Enterobacter; Observation; Microbial Sensitivity Tests; Tigecycline; Anti-Bacterial Agents; 3. Good health; Klebsiella pneumoniae; 03 medical and health sciences; Klebsiella; Multigene Family; Escherichia coli; Humans; Phylogeny; Plasmids

The plasmid-mediated tigecycline resistance gene cluster tmexCD1-toprJ1 and other variants have been detected in a variety of strains from multiple sources, including human-derived strains. In addition to tigecycline, these tmexCD-toprJ -like gene clusters reduce susceptibility of the host strain to many other antimicrobials.