Unraveling the Microbiome of Necrotizing Enterocolitis: Insights in Novel Microbial and Metabolomic Biomarkers

• DOI: 10.1128/spectrum.01176-21
• Publication Date: 2021-10-27T14:31:22Z
• Authors: Chiara Tarracchini; Christian Milani; Giulia Longhi; Federico Fontana; Leonardo Mancabelli; Roberta Pintus; Gabriele Andrea L...; Giulia Alessandri; Rosaria Anzalone; Alice Viappiani; Francesca Turroni; Michele Mussap; Angelica Dessì; Flaminia Cesare M...; Antonio Noto; Anna De Magistris; Marine Vincent; Sergio Bernasconi; Jean-Charles Picaud; Vassilios Fanos; Marco Ventura
• Keywords: Necrotizing Enterocolitis; Dysbiosis; Enterocolitis

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease occurring predominantly in premature infants whose etiology still not fully understood. In this study, the analysis of infant fecal samples through shotgun metagenomics approaches revealed marked reduction intestinal (bio)diversity and an overgrowth (opportunistic) pathogens associated with NEC development.