SARS-CoV-2 Convalescent Sera Binding and Neutralizing Antibody Concentrations Compared with COVID-19 Vaccine Efficacy Estimates against Symptomatic Infection

• DOI: 10.1128/spectrum.01247-22
• Publication Date: 2022-07-20T13:02:34Z
• Authors: Amy J. Schuh; Panayampalli S. S...; Stephanie Dietz; Lara Bull-Otterson; Myrna Charles; Chris Edens; Jefferson M. Jones; Kristina L. Bajema; Kristie E. N. Clarke; L. Clifford McDonald; Sadhna Patel; Kendra Cuffe; Natalie J. Thornburg; Jarad Schiffer; Kelly Chun; Monique Bastidas; Manory Fernando; Christos J. Petro...; Terri Wrin; Suqin Cai; Dot Adcock; Deborah Sesok-Piz...; Stanley Letovsky; Alicia M. Fry; Aron J. Hall; Adi V. Gundlapalli
• Keywords: 2019-20 coronavirus outbreak; Sars virus; Betacoronavirus

Although COVID-19 vaccine efficacy (VE) studies have estimated antibody concentrations that correlate with protection from COVID-19, how these estimates compare to those generated in response SARS-CoV-2 infection is unclear. We assessed quantitative neutralizing and binding using standardized assays on serum specimens collected COVID-19-unvaccinated persons detectable antibodies.