Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin

• DOI: 10.1128/spectrum.01382-24
• Publication Date: 2024-12-10T14:05:24Z
• Authors: Bayazit Yunusbayev; Anna Bogdanova; Nadezhda Nadyrchenko; Lavrentii Danilov; Viktor Bogdanov; Grigory Sergeev; Radick Altinbaev; Fanil Bilalov; Milyausha Yunusbaeva
• Keywords: Dysbiosis

Many studies have reported gut microbiome alterations in psoriasis patients, suggesting dysbiosis. While evidence for dysbiosis and its link to pathogenesis remains inconclusive, murine models of suggest that develop response psoriasis-like inflammation. Hence, the dominant narrative about alterations' impact on disease should be evaluated critically with more data a well-powered approach. In this case-control study, we used deep sequencing fecal samples from 53 patients 47 healthy donors reconstruct strain/species-level content microbiome. Unlike previous studies, first identified matched pairs each patient adjust variability increase power. We found no depleted community diversity apparent divergence structure between individuals. However, our matched-pair approach subtle but systematic select bacteria among e.g.,