Phenotypic Detection of Hemin-Inducible Trimethoprim-Sulfamethoxazole Heteroresistance in Staphylococcus aureus

• DOI: 10.1128/spectrum.01510-21
• Publication Date: 2021-10-27T14:32:22Z
• Authors: Dennis Nurjadi; Quan Chanthalangsy; Elfi Zizmann; Vanessa Stuermer; Maximilian Moll; Sabrina Klein; Sébastien Boutin; Klaus Heeg; Philipp Zanger
• Keywords: 0301 basic medicine; Staphylococcus aureus; MRSA; Microbial Sensitivity Tests; Moths; Staphylococcal Infections; Microbiology; QR1-502; Anti-Bacterial Agents; 3. Good health; antibiotic susceptibility testing; 03 medical and health sciences; Phenotype; Drug Resistance, Multiple, Bacterial; Trimethoprim, Sulfamethoxazole Drug Combination; Animals; Hemin; Humans; hemin; heteroresistance; co-trimoxazole; Research Article

Staphylococcus aureus is one of most important pathogens in clinical medicine. Besides its virulence, the acquisition or emergence of resistance toward antibiotic agents, in particular to beta-lactam antibiotics (methicillin-resistant S. aureus [MRSA]), poses a major therapeutic challenge.