Mutasynthetic Production and Antimicrobial Characterization of Darobactin Analogs

• DOI: 10.1128/spectrum.01535-21
• Publication Date: 2021-12-22T16:25:32Z
• Authors: Nils Böhringer; Robert Green; Yang Liu; Ute Mettal; Michael Marner; Seyed Majed Modaresi; Roman P. Jakob; Zerlina G. Wuisan; Timm Maier; Akira Iinishi; Sebastian Hiller; Kim Lewis; Till F. Schäberle
• Keywords: Proof of concept

Therapeutic options to combat Gram-negative bacterial pathogens are dwindling with increasing antibiotic resistance. This study presents a proof of concept for the heterologous-expression approach expand on novel class darobactins and generate analogs different activities pharmacokinetic properties.