Kaempferol-Driven Inhibition of Listeriolysin O Pore Formation and Inflammation Suppresses Listeria monocytogenes Infection

• DOI: 10.1128/spectrum.01810-22
• Publication Date: 2022-07-20T13:00:39Z
• Authors: Tingting Wang; Baichen Liu; Can Zhang; Tianqi Fang; Ying Ding; Ge Song; Siqi Zhang; Linlin Shi; Xuming Deng; Jianfeng Wang
• Keywords: Inflammation; 0301 basic medicine; Bacterial Toxins; Listeria monocytogenes; 3. Good health; Hemolysin Proteins; Mice; 03 medical and health sciences; Animals; Listeriosis; Kaempferols; Heat-Shock Proteins; Research Article

Currently, we are facing a global crisis of antibiotic resistance, and novel alternative approaches are urgently needed to curb L. monocytogenes infection. Our study demonstrated that kaempferol alleviated L. monocytogenes infection via suppressing LLO pore formation and inflammation response, which might represent a novel antimicrobial-independent strategy to curb listeriosis.