Positive Effect of Lactobacillus acidophilus EG004 on Cognitive Ability of Healthy Mice by Fecal Microbiome Analysis Using Full-Length 16S-23S rRNA Metagenome Sequencing

• DOI: 10.1128/spectrum.01815-21
• Publication Date: 2022-01-12T15:31:31Z
• Authors: Soomin Jeon; Hyaekang Kim; Jina Kim; Donghyeok Seol; Jinchul Jo; Youngseok Choi; Seoae Cho; Heebal Kim
• Keywords: Male; Nanopore sequencing; gut microbiome; Microbiology; Feces; Mice; 03 medical and health sciences; Cognition; cognitive ability; Brain-Gut Axis; Animals; 2. Zero hunger; 0303 health sciences; gut-brain axis; Probiotics; Neurodegenerative Diseases; Biodiversity; QR1-502; Gastrointestinal Microbiome; 3. Good health; Lactobacillus acidophilus; Mice, Inbred C57BL; Disease Models, Animal; Lactobacillus; RNA, Ribosomal, 23S; Metagenome; Research Article

Recently, the concept of the “gut-brain axis” has risen and suggested that microbes in the GI tract affect the brain by modulating signal molecules. Although many pieces of research were reported in a short period, a signaling mechanism and the effects of a specific bacterial strain are still unclear.