Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles

• DOI: 10.1128/spectrum.01943-22
• Publication Date: 2022-12-20T09:02:05Z
• Authors: Cindy Y. Ly; Jessica Pfannenstiel; Anil Pant; Zhilong Yang; Anthony R. Fehr; Maxim S. Rodzkin; David J. Davido
• Keywords: coronavirus; 610; Herpesvirus 1, Human; Microbiology; Immediate-Early Proteins; Cell Line; Mice; Viral Proteins; 03 medical and health sciences; herpesvirus; aurora kinases; kinase inhibitors; Animals; RNA Viruses; Life Cycle Stages; 0303 health sciences; Herpesvirus; Herpes Simplex; DNA; Aurora kinases; HSV-1; QR1-502; 3. Good health; Coronavirus; poxvirus; Kinase inhibitors; Poxvirus; RNA; Research Article

We have demonstrated that aurora kinases play a role during HSV-1 lytic infection. Three aurora kinase inhibitors significantly impaired HSV-1 immediate-early gene expression.