IL-6 Prevents Lung Macrophage Death and Lung Inflammation Injury by Inhibiting GSDME- and GSDMD-Mediated Pyroptosis during Pneumococcal Pneumosepsis

• DOI: 10.1128/spectrum.02049-21
• Publication Date: 2022-03-17T13:00:24Z
• Authors: Xuemei Gou; Wenchun Xu; Yusi Liu; Yang Peng; Wenlong Xu; Yibing Yin; Xuemei Zhang
• Keywords: Pyroptosis; Pneumococcal pneumonia

Pneumococcal pneumonia has been a significant cause of morbidity and mortality throughout human history. Failing to control pneumococcal resolve ongoing inflammation in host can sepsis, namely pneumosepsis, death ensues. Few theories have suggested an optimally therapeutic option for this infectious disease.